Blood exchange in small animals is an emerging approach for systems research on aging

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  • Villeda, SA et al. The aging systemic milieu negatively regulates neurogenesis and cognitive function. Nature 47790–96 (2011).

    CASE
    Article

    Google Scholar

  • Villeda, SA et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat. Med. 20659–663 (2014).

    CASE
    Article

    Google Scholar

  • Loffredo, FS et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac enlargement. Cell 153828–839 (2013).

    CASE
    Article

    Google Scholar

  • Conboy, IM et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433760–764 (2005).

    CASE
    Article

    Google Scholar

  • Conboy, IM & Rando, TA Heterochronic parabiosis for studying the effects of aging on stem cells and their niches. Cell cycle 112260-2267 (2012).

    CASE
    Article

    Google Scholar

  • Conboy, MJ, Conboy, IM & Rando, TA Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging cell. 12525–530 (2013).

    CASE
    Article

    Google Scholar

  • Elabd, C. et al. Oxytocin is an age-specific circulating hormone that is necessary for the maintenance and regeneration of muscle. Nat. Common. 54082 (2014).

    CASE
    Article

    Google Scholar

  • Yousef, H. et al. Aged blood alters the activity of neural precursors in the hippocampus and activates microglia via the cerebral endothelial cell VCAM1. Nat. Med. 25988-1000 (2019).

    CASE
    Article

    Google Scholar

  • Yousef, H. et al. Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same aged mammal. Oncotarget 611959-11978 (2015).

    Article

    Google Scholar

  • Castellano, JM et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature 544488–492 (2017).

    CASE
    Article

    Google Scholar

  • Yousef, H. et al. Age-associated increase in BMP signaling inhibits hippocampal neurogenesis. Stem cells 331577-1588 (2015).

    CASE
    Article

    Google Scholar

  • Yousef, H. et al. Proteins secreted by hESCs can be enriched for multiple regenerative therapies by heparin binding. Aging 5357–372 (2013).

    CASE
    Article

    Google Scholar

  • Carlson, ME et al. Relative roles of TGF-β1 and Wnt in the systemic regulation and aging of satellite cell responses. aging cell 8676–689 (2009).

    CASE
    Article

    Google Scholar

  • Carlson, ME, Silva, HS & Conboy, IM Aging signal transduction pathways and pathology. Exp. Cell Res. 3141951-1961 (2008).

    CASE
    Article

    Google Scholar

  • Egerman, MA et al. GDF11 increases with age and inhibits skeletal muscle regeneration. Metab cell. 22164-174 (2015).

    CASE
    Article

    Google Scholar

  • Smith, LK et al. β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat. Med. 21932–937 (2015).

    CASE
    Article

    Google Scholar

  • Conboy, IM, Conboy, MJ & Rebo, J. Systemic Issues: A Perspective on Aging and Stem Cell Rejuvenation. Aging seven754–765 (2015).

    CASE
    Article

    Google Scholar

  • Schaffer, DV & Gage, FH Neurogenesis and Neuroadaptation. Neuromol. Med. 51–9 (2004).

    CASE
    Article

    Google Scholar

  • Bruel-Jungerman, E., Laroche, S. & Rampon, C. New neurons in the dentate gyrus are implicated in the expression of enhanced long-term memory following environmental enrichment. EUR. J. Neurosci. 21513-521 (2005).

    Article

    Google Scholar

  • Mehdipour, M. et al. Rejuvenation of the tissues of the three germ layers by exchanging old blood plasma with a saline-albumin solution. Aging 128790–8819 (2020).

    CASE
    Article

    Google Scholar

  • Mehdipour, M. et al. Plasma dilution improves cognition and attenuates neuroinflammation in aged mice. Geroscience https://doi.org/10.1007/s11357-020-00297-8 (2020).

  • Rebo, J. et al. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nat. Common. seven13363 (2016).

    CASE
    Article

    Google Scholar

  • Esser, F., Masselter, T. & Speck, T. Silent Pumps: A Comparative Thematic Overview of the Peristaltic Pumping Principle in Living Nature, Engineering, and Biomimetics. Adv. Information. System 11900009 (2019).

    Article

    Google Scholar

  • Horobin, JT, Sabapathy, S. & Simmonds, MJ Repetitive supraphysiological shear stress impairs red blood cell deformability and induces hemolysis. Artif. Organs 411017-1025 (2017).

    Article

    Google Scholar

  • Zhang, T et al. Investigation of flow-induced hemolysis using novel quilt-type blood shear devices. Artif. Organs 351180-1186 (2011).

    Article

    Google Scholar

  • Finerty, JC & Panos, TC Parabiosis poisoning. proc. Soc. Exp. Biol. Med. 76833–835 (1951).

    CASE
    Article

    Google Scholar

  • Finerty, JC Parabiosis in physiological studies. Physiol. Round. 32277–302 (1952).

    CASE
    Article

    Google Scholar

  • Horowitz, AM et al. Blood factors transfer the beneficial effects of exercise on neurogenesis and cognition to the aging brain. Science 369167–173 (2020).

    CASE
    Article

    Google Scholar

  • DeMiguel, Z. et al. Exercise plasma boosts memory and dampens brain inflammation via clusterin. Nature (2021) https://doi.org/10.1038/s41586-021-04183-x

  • Zhang, G., Budker, V. & Wolff, JA Elevated levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hmm. Gene Ther. ten1735–1737 (1999).

    CASE
    Article

    Google Scholar

  • McKeen, LW Introduction to fatigue of plastics and elastomers. Fatigue and tribological properties of plastics and elastomers 3rd ed. (Elsevier, 2016); https://doi.org/10.1016/B978-0-323-44201-5.00001-0

  • McKeen, LW Introduction to the tribology of plastics and elastomers. Fatigue and tribological properties of plastics and elastomers 3rd ed. (Elsevier, 2016); https://doi.org/10.1016/B978-0-323-44201-5.00002-2

  • Ventola, CL Medical applications for 3D printing: current and projected uses. P&T 39704–711 (2014).

    Google Scholar

  • Mastellos, DC, Reis, ES, Ricklin, D., Smith, RJ & Lambris, JD Completing C3-targeted therapy: replacing long-held claims with evidence-based discovery. Immunol Trends. 38383–394 (2017).

    CASE
    Article

    Google Scholar

  • Ricklin, D., Hajishengallis, G., Yang, K. & Lambris, JD Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11785–797 (2010).

    CASE
    Article

    Google Scholar

  • Kolev, M., Le Friec, G. & Kemper, C. Complement – ​​tapping into new effector sites and systems. Nat. Rev. Immunol. 14811–820 (2014).

    CASE
    Article

    Google Scholar

  • Hajishengallis, G. & Lambris, JD Microbial manipulation of receptor crosstalk in innate immunity. Nat. Rev. Immunol. 11187-200 (2011).

    CASE
    Article

    Google Scholar

  • Cardoso, AL et al. Towards biomarkers of frailty: gene candidates and regulated pathways in aging and age-related diseases. Aging Res. Round. 47214-277 (2018).

    CASE
    Article

    Google Scholar

  • Niyonzima, N. et al. Activation of complement by cholesterol crystals triggers a subsequent cytokine response. Mol. Immunol. 8443–50 (2017).

    CASE
    Article

    Google Scholar

  • Björk, I. & Lindahl, U. Mechanism of anticoagulant action of heparin. Mol. Cell. Biochemistry. 48161–182 (1982).

    Article

    Google Scholar

  • Chuang, Y.-J., Swanson, R., Raja, SM & Olson, ST Heparin enhances antithrombin specificity for thrombin and factor Xa independent of central loop reactive sequence: evidence from an exosite determinant of factor Xa specificity in heparin-activated antithrombin. J. Biol. Chem. 27614961–14971 (2001).

    CASE
    Article

    Google Scholar

  • Weitz, JI New anticoagulants for the treatment of venous thromboembolism. Traffic 110I-19–I-26 (2004).

    Google Scholar

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